2159 Dorothy Walker, Jessica Jones

2111 Todd White, Jessica Jones

2163 Washburn, Jessica Jones

2177 Todd, Punisher

2133 Brick, AoS

2088 Tone, Luke Cage

2065 Josh Scarino, SM Far From Home

2011 Joe, Punisher

2128 Christian Ward, AoS

2124 Frank Delcourt, AoS

Cleaned up clues:
1763. From a commercial; based on comics; 00s; Fantastic Four by Stan Lee, Jack Kirby; student if any; New York City?; could fire missiles, not in the sense that the comics version can; unable to determine ****N TOR**
1781. From a commercial; based on comics; 00s; Incredible Hulk by Stan Lee, Jack Kirby; unrevealed; United States; got angry at cashier at grocery store; unable to determine **LK / *IN****
1978. From a TV show; based on comics; 10s; Incredible Hulk by Stan Lee, Jack Kirby; No; doctor (presumably nuclear physicist); United States; participated in a pregnancy related function; unable to determine **LK
2001. From a commercial; based on comics; 10s; Amazing Fantasy by Stan Lee, Steve Ditko; student?; New York City; fought multiple comics based foes of his; Julie Taymor, Glen Berger, Roberto Aguirre-Sacasa? S*I*ER-**N
2008. Original TV show character; 10s; Yes; criminal/restaurant worker; New York City; participated in a duel with main character; Dwain Worrell *N*REI VEZNIKOV
2012. From a commercial; based on comics; 20s; Avengers by David Michelinie, George Pérez; presumed criminal; Paris?; battled two comics-baed heroes whose code names began with the same word; unable to determine T*SK**STER
2023. From a commercial; based on comics; 10s; Strange Tales by Jim Starlin; unrevealed; United States?; did back flips; David Love ***OR*
2037. From a short; based on comics; 10s; Incredible Hulk by Roy Thomas, Herb Trimpe; Yes; terrorist posing as documentary filmmaker; Georgia; interviewed penitentiary inmate; comics version is non-villainous Drew Pearce ***KSON NORRISS
2038. Original TV show character; 10s; Yes; mercenary; decline but alien world; posessed by parasitic creature; Brent Fletcher, Craig Titley *OYLE  [LOCKED; only one letter remaining; letters found at time of locking:  EFIKLNORSTVWYZ]
2043. From a commercial; based on comics (different real name) and real person; 10s?; Incredible Hulk by Stan Lee, Jack Kirby; furniture store owner; Victoria, BC; got angry when employees told him they were running out of room; unable to determine, but the actor may be one of them ***K (*OR*Y *O**) / *O**'S F*RNIT*RE
2047. From a TV show; based on comics; 10s; Power Man by Don McGregor, George Tuska; Yes; criminal; New York City; sentence voided due to the conviction being tainted; Cheo Hodari Coker *ONTRELL "*O*KRO***" ***ILTON
2048. Original TV show character; 10s; Yes; student if any; New York City; accompanied mom  to community centre to get help with permanent citizenship; M. Raven Metzner L*N* TS*I  [LOCKED; only one letter remaining; letters found at time of locking:  EFIKLNORSTVWYZ]
2050. From a commercial; based on comics; 10s; Amazing Fantasy by Stan Lee, Steve Ditko; presumed student; United States; captured crooks with kid's help; unable to determine S*I*ER-**N / S*I*ER-M** *OTORIZE* *E* *L*STER
2051. Original movie character; 10s; Yes; apparent athlete (softball); San Francisco; learned that his girlfriend's employer had a large safe in his house; Edgar Wright, Joe Cornish, Adam McKay, Paul Rudd ***LOS
2052. Original movie character; 10s; Yes; high school student; New York City; took part in field trip to Europe; Chris McKenna, Erik Sommers Y*S*IN *ONETTE
2070. Original TV show character; 10s; Yes; federal agency psychologist; New York City; assigned to evaluate major villain; Sonay Hoffman [*O*TOR] *Y**N
2071. Original TV show character; 10s; Yes; unrevealed; Portland, Oregon; posed as sister (2114) to keep her safe; Marcus Dalzine ***REE RI***R*S
2073. Original TV show character; 10s; Yes; stolen car business criminal; New York City; attempted to torture someone; Dario Scardapane **Z*R
2075. Original TV show character; 10s; Yes; criminal; New York City; member of Hand who fought major villain and main character; Ian Stokes *LE*I
2080. Original TV show character; 10s; Yes; unrevealed; New York City; invited to dinner with aunt and uncle in what proved to be an attempt to set him up with major supporting character; Sonay Hoffman **SON ELLISON
2083. Original TV show character; 10s; Yes; unrevealed; New York City; helped family member move into an apartment; Melissa Rosenberg *OR*E
2088. Original TV show character; 10s; Yes; aide; Harlem; handed boss/major villain some hand lotion; Cheo Hodari Coker TON*  [LOCKED; only one letter remaining; due to a screw up, one of the other letters should have been the one obscured at time of locking]
2090. Original TV show character; 10s; Yes; police commissioner; New York City; with DA, approached by FBI for discussion of major villain and latter's imprisonment; Jim Dunn ***IS *I*OLIN*
2091. Original TV show character; 10s; Yes; SHIELD agent; Alaska; helped maintain security of base from Hydra; Jed Whedon, Maurissa Tancharoen [**ENT] **YLIN
2092. Original TV show character; 10s; Yes; prison guard; United States; escorted villain to prison cell in the 1940s; Michele Fazekas, Tara Butters **RY TOWER
2095. Original TV show character; 10s; Yes; private military firm agent, posed as police officer; New York City; tasked by major villain to kidnap someone's family; Felicia D. Henderson ***K
2102. Original TV show character; 10s; Yes; scientist; New York City; experimented on son in order to save him from his degenerative brain disease; Hilly Hicks, Jr. *O*ISE T*O**SON
2103. Original TV show character; 10s; Yes; patient; New York City; committed to psychiatric hospital after an incident at a pharmacy, and was diagnosed as bipolar with mixed affective episodes layered atop a substance abuse disorder; Scott Buck SI*ON  [LOCKED; only one letter remaining; letters found at time of locking: FIKNOSTVYZ]
2109. Original TV show character; 10s; Yes; possible student; New Orleans; on behalf of a friend, helped ambush main character as the latter left an opera house; Joe Pokaski *RE*ORY  [LOCKED; only one letter remaining; letters found at time of locking: EFIKNORSTVYZ]
2110. Original TV show character; 10s; Yes; university student; Seville, Spain; Norse Mythology class teacher gave her a week to rewrite a paper; Monica Owusu-Breen ELEN*  [LOCKED; only one letter remaining; letters found at time of locking:  EFIKLNORSTVWYZ]
2113. From a TV show; based on earlier character same continuity; 10s; Partial; special organization employee; Unied States; from a reality where most of the Earth was destroyed and she adopted a girl; James C. Oliver, Sharla Oliver *ELIN** **Y
2114. Original TV show character; 10s; Yes; unrevealed; Portland, Oregon; after being burned alive, her sister (2071) posed as her to keep her safe; Marcus Dalzine ZOE RI***R*S
2115. Original TV show character; 10s; Yes; insurance company manager; New York City; embezzed millions of dollars from her employees' pension accounts; Jamie King *EYN* *IN*ER
2135. Original TV show character; 10s; Yes; mobster; Harlem; joined in assassination attempt on main character; Brent Fletcher *RN*STO   [LOCKED; only one letter remaining; letters found at time of locking: FIKNORSTVYZ]
2140. Original TV show character; 10s; Yes; former soldier; Oahu; helped major character during his exile on Earth; Scott Buck ***LO
2144. Original TV show character; 10s; Yes; stolen car gang member; New York City; was ordered to dispose of a hostage; Dario Scardapane ***I
2147. Original TV show character; 10s; Yes; cameraman; New York City; filed duel between main character and main villain; Aida Mashaka Croal, Cheo Hodari Coker F*RLEY  [LOCKED; only one letter remaining; letters found at time of locking:  EFIKLNORSTVWYZ]
2148. Original TV show character; 10s; Yes; police officer; New York City; after the death of someone in this collage, he escorted major supporting character to the apartment; Lisa Randolph *I*KETT
2155. Original TV show character; 10s; Yes; unrevealed; Tijuana; best man at wedding; Brent Fletcher S**NEI*ER
2157. Original TV show character; 10s; Yes; personal assistant; New York City; hid the fact that major villain was still alive; Scott Buck KY*E  [LOCKED; only one letter remaining; letters found at time of locking: EFIKNORSTVYZ]
2162. Original TV show character; 10s; Yes; special organization employee/hotel manager; Portland, Oregon; in charged of keeping possessed people sedated; Paul Zbyszewski FINN *ILLER  [LOCKED; only one letter remaining; letters found at time of locking:  EFIKLNORSTVWYZ]
2164. From a commercial; based on comics; 10s; Captain America Comics by Joe Simon, Jack Kirby; presumed student; New York City?; joined teammates in battling robots; unable to determine ***T*IN **ERI** / *VEN*ERS **E OF *LTRON *ERO *E*R
2169. Original TV show character; 10s; Yes; former ambulance driver; New York City; had a stroke after losing both kidneys (main villain responsible); Micah Schraft ***K *ENTON
2171. From a commercial; based on mythology; 10s; Norse mythology; United States; with allies, faced off against likely adoptive brother; unable to determine T*OR   [LOCKED; only one letter remaining; letters found at time of locking: FIKNORSTVYZ]
2186. Original TV show character; 10s; Yes; mercenary group leader; Michigan; tasked to find and apprehend someone; Steve Lightfoot **RLEN* OLIN
2188. Original TV show character; 10s; Yes; unrevealed; New York City; hostel resident in the 1940s; Eric Pearson S*R**
2189. Original TV show character; 10s; Yes; chef; New York City; someone tried to kill him for overcooking his steak; Jesse Harris **S**R **R*
2191. Original TV show character; 10s; Yes; police officer; New York City; was in van that main character broke out of; Akela Cooper, Charles Murray *IKEY  [LOCKED; only one letter remaining; letters found at time of locking: EFIKNORSTVYZ]
2193. Original TV show character; 10s; Yes; criminal gang member; New York City; killed boss on behalf of another villain; name is also surname of Electric Company character; Declan De Barra *R*NK

For the number clues before, *= newly added +=moved up from "Other Characters...)

LOCKED CHARACTERS
2038
2048
2088
2103
2109
2110
2135
2147
2157
2162
2171
2191

OTHER CHARACTERS WHO SHOULD BE EASY TO ID NOW (not a complete list)
2008
2012
2037
2164

Broad clues:
Many special realities can be found above, and at least one character from each is still on the board (exact totals remaining except for the first two): The Destroyed Earth timeline, the Chronicom timeline

New Orleans usually means Cloak and Dagger. Los Angeles is usually Runaways, She-Hulk, or Agents of SHIELD. The pre-disaster Lighthouse (Agents of SHIELD) is located in the US side of Lake Ontario, which makes it New York State. New Jersey usually signifies Jessica Jones or Ms. Marvel. Portland Oregon usually signifies Helstrom.

One of the Conan characters is from a skit previously identified, the other from a skit not previously identified.

Multiple characters are Lorraine Hotel residents

Tally (will refresh later):
Name    #
Iron Fist    6
Jessica Jones    6
Luke Cage    5
Agents of SHIELD    4
Punisher TV    4
Daredevil TV    3
Agent Carter    3
Helstrom    3
Ant-Man    1
[toy commercial] 1
Captain America: The Winter Soldier    1
[theatre chain commercial]    1
Cloak & Dagger    1
Conan    1
[furniture store commercial]    1
Fantastic 4 - Big Hands & Human Torch - Toy TV Commercial - TV Spot - TV Ad - Biz Toys    1
Inhumans    1
Marvel Avengers Campus - Disneyland Paris    1
Marvel One-Shot: All Hail the King    1
Marvel Universe Live! Age of Heroes     1
Moon Knight    1
Spider-Man: Far From Home    1
Spider-Man : Turn Off The Dark Commercial    1
[another toy commercial]    1
Target commercial (Avengers)    1

Name
Albert Ueligitone
Alex Wyse
Amir Talai
Andre Jackson
Antoni Corone
Ben Kahre
Bowman Wright
Cameron Diskin
Camille Sullivan
Camille Sullivan
Carlos Aviles
Chris Carfizzi
Curran Connor
David Meunier
Dorian Crossmond Missick
Garcelle Beauvais
Gerald Webb
James Hindman
John Garrett Greer
John Scurti
Joshua Rivera
Joyce Greenleaf
Kara Gibson
Lisa Emery
Lori Hammel
Max Baker
Ming-Na Wen
Nikita Bogolyubov
None (CGI)
Owen Burke
Preston Schrag
Reeve Carney or Justin Matthew Sargent possibly
René Ifrah
Roberto De Felice
Samuel Encarnacion
Scoot McNairy
Scott Kruse
Self (non-powered identity)
Sky Lakota-Lynch
Solomon Shiv
Stefanos Miltsakakis
Sylvia Brindis
Teri Reeves
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Vivi Howard
Yasmin Mwanza

 

2088 is correct; list updated.

2171 Thor, Avengers Little Avengers Target commercial

2001 Spider-Man, Spider-Man : Turn Off The Dark Commercial 

2043 Hulk (Gordy Dodd), Dodd's Furniture commercial